Andy Murray has failed to reach the semi-finals of the US Open for the fourth consecutive year.
The British No.1 was beaten by the Japanese No.1 Kei Nishikori 1-6, 6-4, 4-6, 6-1, 7-5 in just under four hours.
Murray stormed the first set, winning 6-1 and when he broke early in the second it looked as though he could be heading for an easy win.
But Nishikori broke back. The match was then delayed while the roof was closed and when both played eventually returned to the court Nishikori went on to level the match via a tie break.